Trevor Lawrence throws three TDs as the Jaguars rout the Colts 42-7 in the rain

Trevor Lawrence threw three touchdown passes on 14 attempts, and the Jacksonville Jaguars beat the Indianapolis Colts 42-7 in the rain on Sunday for their 12th straight home win in the series.

Lawrence went 10 of 14 for 210 yards. He opened the scoring with a 12-yard touchdown to Brian Thomas Jr., the recently benched receiver, then found rookie Nate Boerkircher for 31 yards. Bhayshul Tuten broke three tackles on a 39-yard touchdown run, per the AP recap on ESPN, and Rayuan Lane III intercepted Daniel Jones and went 92 yards for a touchdown with 10 seconds left in the half. The 28-0 halftime lead was the third-largest in franchise history.

Chris Rodriguez Jr. added a 28-yard touchdown run in the third quarter, and Lawrence hit Tuten on a 25-yard screen to close it. Tuten ran for 104 yards on 16 carries, his first 100-yard rushing game, and caught two passes for 55 yards. Jacksonville ran for 183 yards and has won seven straight regular-season home games, outscoring opponents 271-75 in them.

The game came five days after the Colts traded defensive tackle DeForest Buckner and guard Quenton Nelson to start a rebuild. Jonathan Taylor, who the AP says Indianapolis is reportedly willing to trade, had 23 yards on eight carries and lost a fumble on a botched trick play. Jones completed 19 of 28 passes for 144 yards with a touchdown to Josh Downs and two interceptions before he was benched for Anthony Richardson in the fourth quarter. Keenan Allen caught seven passes for 67 yards.

The win was costly for Jacksonville's defense. Nose tackle DaVon Hamilton was carted off with what looked like a significant right knee injury in the second quarter. Safety Eric Murray (elbow), defensive end Travon Walker (ribs), right guard Ezra Cleveland (ankle) and linebacker Branson Combs (arm) were also hurt.

Jacksonville improves to 5-2 coming off its bye. Indianapolis (2-6) has lost four straight and 13 of 15 dating to last season.

What's next: The Jaguars play at Baltimore on Thursday night. The Colts host Dallas next Sunday.